GlutaredoxinV1, Main, Exploration, bibRecord, 000D17

Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.

Identifieur interne : 000D17 ( Main/Exploration ); précédent : 000D16; suivant : 000D18

Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.

Auteurs : Luis Ojeda [États-Unis] ; Greg Keller ; Ulrich Muhlenhoff ; Julian C. Rutherford ; Roland Lill ; Dennis R. Winge

Source :

The Journal of biological chemistry [ 0021-9258 ] ; 2006.

RBID : pubmed:16648636

Descripteurs français

English descriptors

KwdEn :
- Cell Nucleus (metabolism), Cytosol (metabolism), Gene Expression Regulation, Fungal (MeSH), Glutaredoxins (MeSH), Glutathione (metabolism), Iron (metabolism), Oxidoreductases (genetics), Oxidoreductases (metabolism), Regulon (physiology), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (physiology), Transcription Factors (genetics), Transcription Factors (metabolism), Transcriptional Activation (physiology).
MESH :
- chemical , genetics : Oxidoreductases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : Glutathione, Iron, Oxidoreductases, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical : Glutaredoxins.
- genetics : Saccharomyces cerevisiae.
- metabolism : Cell Nucleus, Cytosol, Saccharomyces cerevisiae.
- physiology : Regulon, Signal Transduction, Transcriptional Activation.
- Gene Expression Regulation, Fungal.

Abstract

The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis. These factors induce the expression of iron regulon genes in iron-deficient yeast but are inactivated in iron-replete cells. Iron inhibition of Aft1/Aft2 was previously shown to be dependent on mitochondrial components required for cytosolic iron sulfur protein biogenesis. We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells. Cells lacking both glutaredoxins show constitutive expression of iron regulon genes. Overexpression of Grx4 attenuates wild type Aft1 activity. The thioredoxin-like domain in Grx3 and Grx4 is dispensable in mediating iron inhibition of Aft1 activity, whereas the conserved cysteine that is part of the conserved CGFS motif in monothiol glutaredoxins is essential for this function. Grx3 and Grx4 interact with Aft1 as shown by two-hybrid interactions and co-immunoprecipitation assays. The interaction between glutaredoxins and Aft1 is not modulated by the iron status of cells but is dependent on the conserved glutaredoxin domain Cys residue. Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.

DOI: 10.1074/jbc.M602165200
PubMed: 16648636

Affiliations:

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Le document en format XML

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<author><name sortKey="Ojeda, Luis" sort="Ojeda, Luis" uniqKey="Ojeda L" first="Luis" last="Ojeda">Luis Ojeda</name>
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<author><name sortKey="Keller, Greg" sort="Keller, Greg" uniqKey="Keller G" first="Greg" last="Keller">Greg Keller</name>
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<author><name sortKey="Muhlenhoff, Ulrich" sort="Muhlenhoff, Ulrich" uniqKey="Muhlenhoff U" first="Ulrich" last="Muhlenhoff">Ulrich Muhlenhoff</name>
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<author><name sortKey="Rutherford, Julian C" sort="Rutherford, Julian C" uniqKey="Rutherford J" first="Julian C" last="Rutherford">Julian C. Rutherford</name>
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<author><name sortKey="Rutherford, Julian C" sort="Rutherford, Julian C" uniqKey="Rutherford J" first="Julian C" last="Rutherford">Julian C. Rutherford</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Nucleus (metabolism)</term>
<term>Cytosol (metabolism)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Glutaredoxins (MeSH)</term>
<term>Glutathione (metabolism)</term>
<term>Iron (metabolism)</term>
<term>Oxidoreductases (genetics)</term>
<term>Oxidoreductases (metabolism)</term>
<term>Regulon (physiology)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (physiology)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Transcriptional Activation (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation de la transcription (physiologie)</term>
<term>Cytosol (métabolisme)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Fer (métabolisme)</term>
<term>Glutarédoxines (MeSH)</term>
<term>Glutathion (métabolisme)</term>
<term>Noyau de la cellule (métabolisme)</term>
<term>Oxidoreductases (génétique)</term>
<term>Oxidoreductases (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Régulon (physiologie)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Oxidoreductases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term>
<term>Iron</term>
<term>Oxidoreductases</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutaredoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Oxidoreductases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term>
<term>Cytosol</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytosol</term>
<term>Facteurs de transcription</term>
<term>Fer</term>
<term>Glutathion</term>
<term>Noyau de la cellule</term>
<term>Oxidoreductases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Activation de la transcription</term>
<term>Régulon</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Regulon</term>
<term>Signal Transduction</term>
<term>Transcriptional Activation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Fungal</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Glutarédoxines</term>
<term>Régulation de l'expression des gènes fongiques</term>
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<front><div type="abstract" xml:lang="en">The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis. These factors induce the expression of iron regulon genes in iron-deficient yeast but are inactivated in iron-replete cells. Iron inhibition of Aft1/Aft2 was previously shown to be dependent on mitochondrial components required for cytosolic iron sulfur protein biogenesis. We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells. Cells lacking both glutaredoxins show constitutive expression of iron regulon genes. Overexpression of Grx4 attenuates wild type Aft1 activity. The thioredoxin-like domain in Grx3 and Grx4 is dispensable in mediating iron inhibition of Aft1 activity, whereas the conserved cysteine that is part of the conserved CGFS motif in monothiol glutaredoxins is essential for this function. Grx3 and Grx4 interact with Aft1 as shown by two-hybrid interactions and co-immunoprecipitation assays. The interaction between glutaredoxins and Aft1 is not modulated by the iron status of cells but is dependent on the conserved glutaredoxin domain Cys residue. Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.</div>
</front>
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<DateCompleted><Year>2006</Year>
<Month>08</Month>
<Day>18</Day>
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<DateRevised><Year>2014</Year>
<Month>11</Month>
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<ISOAbbreviation>J Biol Chem</ISOAbbreviation>
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<ArticleTitle>Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.</ArticleTitle>
<Pagination><MedlinePgn>17661-9</MedlinePgn>
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<Abstract><AbstractText>The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis. These factors induce the expression of iron regulon genes in iron-deficient yeast but are inactivated in iron-replete cells. Iron inhibition of Aft1/Aft2 was previously shown to be dependent on mitochondrial components required for cytosolic iron sulfur protein biogenesis. We presently show that the nuclear monothiol glutaredoxins Grx3 and Grx4 are critical for iron inhibition of Aft1 in yeast cells. Cells lacking both glutaredoxins show constitutive expression of iron regulon genes. Overexpression of Grx4 attenuates wild type Aft1 activity. The thioredoxin-like domain in Grx3 and Grx4 is dispensable in mediating iron inhibition of Aft1 activity, whereas the conserved cysteine that is part of the conserved CGFS motif in monothiol glutaredoxins is essential for this function. Grx3 and Grx4 interact with Aft1 as shown by two-hybrid interactions and co-immunoprecipitation assays. The interaction between glutaredoxins and Aft1 is not modulated by the iron status of cells but is dependent on the conserved glutaredoxin domain Cys residue. Thus, Grx3 and Grx4 are novel components required for Aft1 iron regulation that most likely occurs in the nucleus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ojeda</LastName>
<ForeName>Luis</ForeName>
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<AffiliationInfo><Affiliation>Departments of Medicine and Biochemistry, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Rutherford</LastName>
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<Author ValidYN="Y"><LastName>Winge</LastName>
<ForeName>Dennis R</ForeName>
<Initials>DR</Initials>
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</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CA 61286</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C090297">AFT1 protein, S cerevisiae</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C516012">Grx4 protein, S cerevisiae</NameOfSubstance>
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Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.

Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae.

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